The essence of conventional or classical scientific mindset shown by probability-based step-by-step “deducto – hypothetico – verificative” way of thinking. But, within “Inverted Paradigm Method (IPM)” totally change in opposite direction. It is called as possibility-based “reverse engineering”, “evidence-based”. The trend using IPM with its variations is prominently exposed since the early 21th century, by the fact that the scientific world occasionally suffering from the “syndrome of the End of Science”, a syndrome where Science getting difficulties in finding answer to many human complex problems. IPM in essence using “Top – down approach”, the approach in which we traces the histories from the “top down”, that is, backward from the present time. Other than that also, because within Data-Information-Knowledge-Wisdom (DIKW) hierarchy continuum, Knowledge (in broad meaning) epistemologically behaving higher level than the behavior of D-I level