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Rajanikanth Vadigepalli

Rajanikanth Vadigepalli's picture

We are interested in understanding the operational principles of mammalian tissue plasticity, renewal, repair and regeneration. A key goal is to develop novel clinical interventions and decision-support systems for regenerative medicine. Our transdisciplinary systems biology strategy is based on a convergence of systems engineering, computational modeling, bioinformatics, functional genomics, high-dimensional data analysis, in vivo interventions, and single cell scale experimental assays. Ongoing collaborative projects focus on liver repair and regeneration, alcoholic liver disease, brainstem neuroinflammation and neuroimmune processes leading to hypertension, cell fate regulation underlying developmental defects, and network modeling of repair in multiple mammalian tissues.