Genética, GSD - Liliana, André, Leonor
Shifting the Burden Archetype (Cite: Gene Bellinger)
Escalation Archetype (Cite: Gene Bellinger)
The limits to growth structure is based on the basic growth structure. And, as should be obvious, nothing grows forever as growth requires resources. Those required resources become a limits to growth.
Limits to Growth Archetype (Cite: Gene Bellinger)
Abstract
High altitude environments challenge the physiology of
mammals mainly due to hypoxic conditions. As a response to this, many mammals
show molecular adaptations e.g. by mutations in the genes encoding the hemoglobins.
This can result in an increase O2 affinity (and thereby a
leftshifted O2 dissociation curve) which will enhance the pulmonary
loading of O2. However, the shift can also hamper the O2 unloading
process to the metabolic tissue. To elucidate this trade-off between loading and
unloading a numerical computer model was made in the program Insigt maker based
on the organism, deer mouse (
Peromyscus
maniculatus). The numerical solution was calculated by the Runge-Kutta
method. A time step (dt) of 0.00001 was chosen, as the results were independent
of dt at this value. This was tested by investigating the residual values of an
interval of dt around 0.00001. The model showed how the trade-off is expressed
at different altitudes and how the degree of advantages/disadvantages varies.
Based on the model it can be suggested that the trade-off is beneficial, when
the hypoxia is severe at high altitude. This is consistent with previously
findings.
Model af O2 transport under hypoxi
Book Summary based on Terry Sampson's summary of Philip Ball's May 2024 Royal Society presentation. A causal loop scaffolding using Gene Bellinger's mc and mr AI prompts for Gemini added in Jan2026. See also Philip Ball's article summary insight
How Life Works Book Summary
Enabling a Happy Tomorrow - EaHT (Gene Bellinger Model)
EaHT (Gene Bellinger Model)
See Gene's excellent explication at
https://www.youtube.com/watch?v=k22rDovFzUE
Conveyor per Gene
The calorie reduction by Gene, copied so I can include stress, high intensity exercise, sleep and carb restriction.
Weight Loss System
WIP Summary of Cell Systems 2024 article Versatile system cores as a conceptual basis
for generality in cell and developmental biology
Core and periphery hypothesis for cells and developmental systems
Gene Expression Model II: regulation
A simple rookie pro workforce supply chain like Gene's insight with optimal intake policy taking into account the target for professionals and the trainees already in the pipeline. See also Gene's insight for data patterns
Trainees to Professionals Hiring Policy
Simplistic Gene Expression Model I: no regulation
Unfolding WIP of Eric Wolstenholme's explanation of hospital congestion from March 2022 Youtube video and online stella presentation. Use of cascading interlinked archetypes. See Kumu version, early discharge boundaries IM for an earlier version and Generic Archetypes IM from Gene and Simpler Version IM
Hospital congestion cascading archetypes
Learning THread for hybrid models including Grimm's ODD and Nate Osgood's ABM Modeling Process and Courses
Dynamic Models Learning Content
As part of becoming familiar with InsightMaker, the purpose of this model is to merely replicate Gene Bellinger's completed "Moose_Wolves" model.
All credit needs to be given to Gene. Thank you InsightMaker.com for making it so easy to rebuilt and model and provide details on equations, algorithms.
Moose Wolves v01
Causal loop diagram illustrating how evolution, in the form of small incremental change (realized through random genetic mutation) paired with natural selection, serves to evolve species.
Additionally, the diagram illustrates the countering effects of genetic drift, which serves to reduce genetic variation by eliminating beneficial genes.
Evolutionary Change (2-Loop)
Adapted from Fig.1.from Ana V Diez Roux (2011) Complex Systems Thinking May Help Us Transcend Current Impasses in Health Disparities Research Am J Public Health 2011;101 1627-1634 http://ajph.aphapublications.org/cgi/content/abstract/101/9/1627?etoc
Genes environment and health disparities
From Fig 12.2 p317 Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis
Development dynamic interactions
From Fig 1.1 p11 Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis. This is a shift in emphasis from statistical correlation to mechanistic causation (p12), including the conditions for the origin and innovation of traits (p13). It overcomes the gradualism, externalism and gene centrism of the Modern Synthesis. Non-gradual change is a property of complex dynamical systems. EvoDevo processes generate particular forms of change rather than others.Genes are followers in the evolutionary process that capture the emergent interactions among environment, development and inheritance into genetic-epigenetic circuits, which are passed to and elaborated on in subsequent generations (p14).
Evolution extended synthesis
