WIP Summary of Cell Systems 2024 article Versatile system cores as a conceptual basis for generality in cell and developmental biology

As part of becoming familiar with InsightMaker, the purpose of this model is to merely replicate Gene Bellinger's completed "Moose_Wolves" model.  

All credit needs to be given to Gene.   Thank you InsightMaker.com for making it so easy to rebuilt and model and provide details on equations, algorithms.  

From Fig 12.2 p317 Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis

Causal loop diagram illustrating how evolution, in the form of small incremental change (realized through random genetic mutation) paired with natural selection, serves to evolve species.

​From Fig 1.1 p11  Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis. This is a shift in emphasis from statistical correlation to mechanistic causation (p12), including the conditions for the origin and innovation of traits (p13). It overcomes the gradualism, externalism and gene centrism of the Modern Synthesis. Non-gradual change is a property of complex dynamical systems. EvoDevo processes generate particular forms of change rather than others.Genes are followers in the evolutionary process that capture the emergent interactions among environment, development and inheritance into genetic-epigenetic circuits, which are passed to and elaborated on in subsequent generations (p14).

The limits to growth structure is based on the basic growth structure. And, as should be obvious, nothing grows forever as growth requires resources. Those required resources become a limits to growth.

Unfolding WIP of Eric Wolstenholme's explanation of hospital congestion from March 2022 Youtube video and online stella presentation. Use of cascading interlinked archetypes. See Kumu version,  early discharge boundaries IM for an earlier version and Generic Archetypes IM from Gene and Simpler Version IM

See Gene's excellent explication at 

The calorie reduction by Gene, copied so I can include stress, high intensity exercise, sleep and carb restriction.

A simple rookie pro workforce supply chain like Gene's insight with optimal intake policy taking into account the target for professionals and the trainees already in the pipeline. See also Gene's insight for data patterns

This is just a test to see if I can duplicate what Gene did in BCtD

Adapted from Fig.1.from Ana V Diez Roux (2011) Complex Systems Thinking May Help Us Transcend Current Impasses in Health Disparities Research Am J Public Health 2011;101 1627-1634 http://ajph.aphapublications.org/cgi/content/abstract/101/9/1627?etoc

 Learning THread for hybrid models including Grimm's ODD and Nate Osgood's ABM Modeling Process and Courses

We want to know the estimated projected Earnings before tax of a 5 year project. For this we have modeled Sales Growth, Cost of goods sold and Admin. expenses applying sensitivity testing by using probability distributions.

Adapted from Fig 2, from Ana V Diez Roux (2011) Complex Systems Thinking May Help Us Transcend Current Impasses in Health Disparities Research Am J Public Health 2011;101 1627-1634  http://ajph.aphapublications.org/cgi/content/abstract/101/9/1627?etoc