Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here

WIP representation of thinking feeling acting and interacting

Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here. See also 2018 N. Hosseinichimeh Plos ONE article for rumination focussed SD simulation

Gross theory of emotion regulation from Saras Chung ISDC 2015  Abstract 

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

WIP Based on Carlos E Perez twitter diagrams and Paul Cisek 2019 paper and talks including explore and exploit behaviours

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

WIP Thyroid HPA axis dynamics based on Kohanin 2022 article and Ch3.5 of Uri Alon's System Medicine book. A series of secrete and grow physiological circuits 

WIP representation of thinking feeling acting and interacting

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Explanation of delays in treatment effect and rebound effects on cessation of anti-depressant SSRI drugs based on Andrews

Small Intestine example from Progress in Biophysics & Molecular Biology Special Issue 2016 From the century of the genome to the century of the organism: New theoretical approaches paper on organization. Compare with Bogdanov (click tag)

Attempt to clarify the differences in the energy balance and carbohydrate insulin obesity models described in Speakman and Hall's 2021 science article See also Nature Metabolism Obesity Causal Model Differences 2024 article and insight

Diagrams from Greene 2017 nejm article Putting the patient back together Social Medicine, Network Medicine, and the Limits of Reductionism

Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here

Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

WIP Perceptual Control Hierarchy of Needs linked to Mental Health using suicide crisis as an example based on Mansell 2021 pct and psychopathology paper Macintyre2021 pct and suicide crisis paper and Carey2014 Method of Levels paper. See also Cisek and Perez brain control circuit evolution IM

WIP based on WHO Decade of Healthy Ageing baseline report  2020 Annex

Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here