Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

WIP From  zenker 2007 article PLoS Computational Biology From Inverse Problems in Mathematical Physiology to Quantitative Differential Diagnoses

Bond Graph Kinetic Modeling Metabolic Map by J LeFevre  http://www.systemdynamics.org/conferences/2004/SDS_2004/PAPERS/379LEFEV.pdf

See also IM-857 and IM-2235 for more detail

Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Layout of insight IM-855 See also IM-2235 for unfolding version

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

Part of Urea Kinetic model for Clearance Experiments

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

ithink example from isee systems using receptors

WIP Thyroid HPA axis dynamics based on Kohanin 2022 article and Ch3.5 of Uri Alon's System Medicine book. A series of secrete and grow physiological circuits 

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Simplified version of IM-852  Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map  Insight 810 

Simplified version of IM-852  Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map  Insight 810 

From Tarek KA Hamid's Book Thinking in Circles About Obesity Springer 2009

Explanation of delays in treatment effect and rebound effects on cessation of anti-depressant SSRI drugs based on Andrews

From p592 Doyle F et al.(2007) Journal of Process Control 17 571-594

abstract

Bond Graph Kinetic Modeling Metabolic Map by J LeFevre  http://www.systemdynamics.org/conferences/2004/SDS_2004/PAPERS/379LEFEV.pdf

See also IM-857 and IM-2235 for more detail

Small Intestine example from Progress in Biophysics & Molecular Biology Special Issue 2016 From the century of the genome to the century of the organism: New theoretical approaches paper on organization. Compare with Bogdanov (click tag)

Diagrams from Greene 2017 nejm article Putting the patient back together Social Medicine, Network Medicine, and the Limits of Reductionism

Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Alternate Layout of insight IM-857 Here Join and Split Flows are unfolded rather than using folders around the Stocks.

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586