Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hep

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

 Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

 Addition of glucagon hormone action to control glucose homeostasis extended from  IM-586

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

Summary of Gizem Aktas M Sc thesis and prize winning paper from ISDC2018 extended  abstract pdf   See also Tom fiddaman's metaSD blog  entry 1 and  entry 2  Note the response time frame of interest is from hours to around 45 days. See  IM-34861  for a broader developmental view
Summary of Gizem Aktas M Sc thesis and prize winning paper from ISDC2018 extended abstract pdf 
See also Tom fiddaman's metaSD blog entry1 and entry 2 Note the response time frame of interest is from hours to around 45 days. See IM-34861 for a broader developmental view
 From Tarek KA Hamid's Book Thinking in Circles About Obesity Springer 2009

From Tarek KA Hamid's Book Thinking in Circles About Obesity Springer 2009

 Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker     Glucose Insulin Model Info:  Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Spr

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker


Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

 Major stocks and flows of Erythropoiesis and Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers

Major stocks and flows of Erythropoiesis and Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers

 Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker     Glucose Insulin Model Info:  Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Spr

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker


Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

 Simplified version of  IM-852   Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map   Insight 810  

Simplified version of IM-852  Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map  Insight 810 

 A simple glucose regulation causal loop diagram taken from Richard O. Foster, 1970: The Dynamics of blood sugar regulation, MSc thesis, MIT Dept of Electrical Engineering, available on the MIT System Dynamics Group Literature Collection and in the MIT Electronic Libraries. See  IM-587  for Addition

A simple glucose regulation causal loop diagram taken from Richard O. Foster, 1970: The Dynamics of blood sugar regulation, MSc thesis, MIT Dept of Electrical Engineering, available on the MIT System Dynamics Group Literature Collection and in the MIT Electronic Libraries. See IM-587 for Addition of Glucagon

 Addition of glucagon hormone action to control glucose homeostasis extended from  IM-586

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

 Working model of Erythropoiesis and Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map   Insight 810   and Simpler Dosing Model at  IM-26182

Working model of Erythropoiesis and Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map  Insight 810  and Simpler Dosing Model at IM-26182

 Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Alternate Layout of insight  IM-857  Here Join and Split Flows are unfolded rather than using folders around the Stocks.

Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Alternate Layout of insight IM-857 Here Join and Split Flows are unfolded rather than using folders around the Stocks.

 Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Layout of insight  IM-855  See also  IM-2235  for unfolding version

Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Layout of insight IM-855 See also IM-2235 for unfolding version

 System Zoo Z111 H Bossel p47 a variant of Michaelis Menten Enzyme Kinetics. See also  IM-854  for Hannon and Ruth and  IM-855  for receptor version and  IM-856  for a bond graph view

System Zoo Z111 H Bossel p47 a variant of Michaelis Menten Enzyme Kinetics. See also IM-854 for Hannon and Ruth and IM-855 for receptor version and IM-856 for a bond graph view

 Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker     Glucose Insulin Model Info:  Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Spr

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker


Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

 Part of Urea Kinetic model for Clearance Experiments

Part of Urea Kinetic model for Clearance Experiments

Dosage per day, Doses per day, Every ? hours, Medicine in Intestines, Drug absorption, Plasma level, Blood volume, Plasma concentration, ​Toxic level, Medicinal level, Drug excretion, Excretion rate, Half-Life
Dosage per day, Doses per day, Every ? hours, Medicine in Intestines, Drug absorption, Plasma level, Blood volume, Plasma concentration, ​Toxic level, Medicinal level, Drug excretion, Excretion rate, Half-Life
 Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hep

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

 From p592 Doyle F et al.(2007) Journal of Process Control 17 571-594   abstract

From p592 Doyle F et al.(2007) Journal of Process Control 17 571-594


abstract
Diagrams from Greene 2017 nejm  article  Putting the patient back together Social Medicine, Network Medicine, and the Limits of Reductionism
Diagrams from Greene 2017 nejm article Putting the patient back together Social Medicine, Network Medicine, and the Limits of Reductionism