Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Layout of insight IM-855 See also IM-2235 for unfolding version
Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.
Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Simplified version of IM-852 Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map Insight 810
Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Simplified version of IM-852 Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map Insight 810
WIP Thyroid HPA axis dynamics based on Kohanin 2022 article and Ch3.5 of Uri Alon's System Medicine book. A series of secrete and grow physiological circuits
Small Intestine example from Progress in Biophysics & Molecular Biology Special Issue 2016 From the century of the genome to the century of the organism: New theoretical approaches paper on organization. Compare with Bogdanov (click tag)
Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Alternate Layout of insight IM-857 Here Join and Split Flows are unfolded rather than using folders around the Stocks.
System Zoo Z111 H Bossel p47 a variant of Michaelis Menten Enzyme Kinetics. See also IM-854 for Hannon and Ruth and IM-855 for receptor version and IM-856 for a bond graph view
