Overview of theory from Progress in Biophysics & Molecular Biology Special Issue 2016 From the century of the genome to the century of the organism: New theoretical approaches paper on organization. See example1 insight and example 2 insight Compare with Bogdanov (click tag)

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here. See also 2018 N. Hosseinichimeh Plos ONE article for rumination focussed SD simulation

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

WIP Physiological circuits insight integrated with other articles on inflammation fibrosis and innate immunity

Additional of glucagon hormone action to control glucose homeostasis

WIP Book Summary 

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Attempt to clarify the differences in the energy balance and carbohydrate insulin obesity models described in Speakman and Hall's 2021 science article See also Nature Metabolism Obesity Causal Model Differences 2024 article and insight

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

Minimal model of glucose kinetics to match description by Bergman 2021 article and Ch1 simulation exercise of Uri Alon's System Medicine book. Layout similar to the Insightmaker BIG Model 

WIP Perceptual Control Hierarchy of Needs linked to Mental Health using suicide crisis as an example based on Mansell 2021 pct and psychopathology paper Macintyre2021 pct and suicide crisis paper and Carey2014 Method of Levels paper. See also Cisek and Perez brain control circuit evolution IM

Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here. See also 2018 N. Hosseinichimeh Plos ONE article for rumination focussed SD simulation

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

WIP Physiological circuits insight integrated after other articles on inflammation fibrosis and innate immunity pictures insight 

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

WIP Extension of the simplified Glucose minimal model (IM) as described in Ch 2 of Uri Alon's System Medicine Book  Values from Mohammed 2019 article. Copied from Mark Heffernan's Stella model (to be hosted)

Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here. See also 2018 N. Hosseinichimeh Plos ONE article for rumination focussed SD simulation

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.