Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Layout of insight IM-855 See also IM-2235 for unfolding version

Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Alternate Layout of insight IM-857 Here Join and Split Flows are unfolded rather than using folders around the Stocks.

Bond Graph Kinetic Modeling Metabolic Map by J LeFevre  http://www.systemdynamics.org/conferences/2004/SDS_2004/PAPERS/379LEFEV.pdf

See also IM-857 and IM-2235 for more detail

Part of Urea Kinetic model for Clearance Experiments

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

ithink example from isee systems using receptors

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Simplified version of IM-852  Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map  Insight 810 

Hannon and Ruth Modeling Dynamic Biological Systems p67

From Tarek KA Hamid's Book Thinking in Circles About Obesity Springer 2009

Working model of Erythropoiesis and Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map  Insight 810  and Simpler Dosing Model at IM-26182

Simplified version of IM-852  Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map  Insight 810 

Major stocks and flows of Erythropoiesis and Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers. See Simulation Insight

Simplified version of IM-852  Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map  Insight 810 

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

Additional of glucagon hormone action to control glucose homeostasis

Simplified version of IM-852  Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map  Insight 810 

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

From p592 Doyle F et al.(2007) Journal of Process Control 17 571-594

A simple glucose regulation causal loop diagram taken from Richard O. Foster, 1970: The Dynamics of blood sugar regulation, MSc thesis, MIT Dept of Electrical Engineering, available on the MIT System Dynamics Group Literature Collection and in the MIT Electronic Libraries. See IM-587 for Addition of Glucagon