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A Susceptible-Infected-Recovered (SIR) disease model with waning immunity

COVID-19 Delta Variant Spread Among Emory Students
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My Insight Covid-19
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The Covid-19 pandemic has introduced a variety of novel and intense difficulties, from dealing with the production network for individual defensive gear (PPE) to changing labor force ability to adapting to monetary misfortune. Amidst these difficulties lies a chance for medical services pioneers to more readily position and change their associations for an eventual fate of unusual amazement. To oversee limit, monetary misfortune, and care overhaul, medical services associations have settled on the basic choice to deliver or lessen labor force or to move numerous representatives to far off work, incorporating clinicians working with telehealth advances. (www.catalyst.nejm.org)


Reference:
Begun, J.W. PhD, Jiang, J.H, PhD,. (2020, October 9). NEJM Catalyst/Innovations in Care Delivery. Health Care Management During Covid-19: Insights from Complexity Science. Retrieved from https://catalyst.nejm.org/doi/full/10.1056/CAT.20.0505

Covid-19 Health Care Complexities and Variables
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Overview:

Overall, this analysis showed a COVID-19 outbreak in Burnie, the government policies to curtail that, and some of the impacts it is having on the Burnie economy.


Variables

The simulation made use of the variables such as; Covid-19: (1): Infection rate. (2): Recovery rate. (3): Death rate. (4): Immunity loss rate etc. 


Assumptions:

From the model, it is apparent that government health policies directly affect the economic output of Burnie. A better health policy has proven to have a better economic condition for Burnie and verse versa.


In the COVID-19 model, some variables are set at fixed rates, including the immunity loss rate, recovery rate, death rate, infection rate, and case impact rate, as this is normally influenced by the individual health conditions and social activities.

Moving forward, we decided to set the recovery rate to 0.7, which is a rate above the immunity loss rate of 0.5, so, the number of susceptible could be diminished over time.


Step 1: Try to set all value variables at their lowest point and then stimulate. 

 

Outcome: the number of those Infected are– 135; Recovered – 218; Cases – 597; Death – 18,175; GDP – 10,879.


Step 2: Try to increase the variables of Health Policy, Quarantine, and Travel Restriction to 0.03, others keep the same as step 1, and simulate


Outcome: The number of those Infected – 166 (up); Recovered – 249 (up); Cases – 554 (down); Death – 18,077 (down); GDP – 824 (down).


With this analysis, it is obvious that the increase of health policy, quarantine, and travel restriction will assist in increase recovery rate, a decrease in confirmed cases, a reduction in death cases or fatality rate, but a decrease in Burnie GDP.


Step 3: Enlarge the Testing Rate to 0.4, variable, others, maintain the same as step 2, and simulate


Outcome: It can be seen that the number of Infected is down to – 152; those recovered down to – 243; overall cases up to – 1022; those that died down to–17,625; while the GDP remains – 824.


In this step, it is apparent that the increase of testing rate will assist to increase the confirmed cases.


Step 4: Try to change the GDP Growth Rate to 0.14, then Tourism Growth Rate to 0.02, others keep the same as step 3, and then simulate the model


Outcome: what happens is that the Infected number – 152 remains the same; Recovered rate– 243 the same; Number of Cases – 1022 (same); Death – 17,625 (same); but the GDP goes up to– 6,632. 


This final step made it obvious that the increase of GDP growth rate and tourism growth rate will help to improve the overall GDP performance of Burnie's economy.

The Recent COVID-19 Outbreak in Burnie Tasmania - Buchi Okafor 546792
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An SIR model for Covid-19

This is a simple example of an SIR model for my Mathematics for Liberal Arts classes at Northern Kentucky University, Spring of 2022.

Let's think about things on the scale of a week. What happens over a week?

With an Ro of 2 (2 people infected for each infected individual, over the course of a week); recovery rate of 1 (every infected person loses their infectiousness after a week), and resusceptible rate of .05 (meaning .05, or a twentieth of the recovered lose their immunity each week), the disease peaks -- does the wave, then waves again before the year is out, then ultimately becomes
"endemic" (that is, it's never going away, which is clear after two years -- that is, a time of 104 weeks). This is like our seasonal flu (only the disease in this simulation doesn't illustrate seasonality -- that requires a more complicated model).

With an Ro of .9, recovery rate of 1, and resusceptible rate of .05, the disease is eliminated.

Masking, social distancing (including quarantining following contact), and quarantines all serve to reduce infectivity. And if we can drive infectivity down far enough, the disease can be eliminated. Other things that help is slowing down the resusceptibility, by vaccinating. Vaccines (in general) impart an immune response that reduces -- or even eliminates -- your susceptibility. We are still learning the extent to which these vaccines impart long-term immunity.

Other tools at our disposal include Covid-19 treatments, which increase the recovery rate, and vaccinations, which reduce the resusceptible rate. These can also serve to help us eradicate a disease, so that it doesn't become endemic (and so plague us forever).

Andy Long
Mathematics and Statistics

Some resources:
  1. Wear a good mask: https://www.cdc.gov/coronavirus/2019-ncov/your-health/effective-masks.html
  2. Gotta catch those sneezes: https://www.dailymail.co.uk/sciencetech/article-8221773/Video-shows-26-foot-trajectory-coronavirus-infected-sneeze.html

MAT115 Covid Simulation
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Covid-19_Systemigram_BradD
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Dieses Causal Loop Diagramm (CLD) versucht in vereinfachter Weisse die Wesentliche Dynamik des Mars-CoV-2 zu veranschaulichen. Der Motor hinter den Infektionen ist offensichtlich eine selbstverstärkende Rückkopplungsschleife, und ausschlaggebend in diesem Bezug ist der R-Wert. Wenn der R-Wert unter 1 liegt, dann heisst das, dass eine infizierte Person während des Zeitraums, in dem sie infektiös ist, weniger als eine andere Person infiziert.  Liegt der Wert über 1, dann steckt die Infizierte mehr als eine andere Person an, und das Virus verbreitet sich exponentiell. Die Schleifen, die blaue Pfeile enthalten, sind negative Rückkopplungsschleifen – sie bremsen die Verbreitung des Virus. Das Diagramm suggeriert, dass der R-Wert als Schlüssel zur Kontrolle der Verbreitung des Virus dienen könnte. Sollte der Wert über 1 steigen, so müssten  Schutzmassnahem eingeführt werden. Ist der Wert unter 1, dann sind die negativen Schleifen dominierend und einige Massnahmen könnten gelockert werden. 

Eine Systemische Sicht auf Covid-19
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Simplified Model_v2
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This System Model presents the cases of COVID-19 in Puerto Princesa City as of June 3, 2021

Insight Author: Pia Mae M. Palay
System Dynamic Model of COVID 19 in Puerto Princesa City
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This Model was developed from the SEIR model (Susceptible, Enposed, Infected, Recovered). It was designed to explore relationships between the government policies regarding the COVID-19 and its impact upon the economy as well as well-being of residents. 

Assumptions:

Government policies will be triggered when reported COVID-19 case are 10 or less;


Government Policies affect the economy and the COV-19 infection negatively at the same time;


Government Policies can be divided as 4 categories, which are Social Distancing, Business Restrictions, Lock Down, Travel Ban, and Hygiene Level, and they represented strength of different aspects;

 

Parameters:

Policies like Social Distancing, Business Restrictions, Lock Down, Travel Ban all have different weights and caps, and they add up to 1 in total;

 

There are 4 cases on March 9th; 

Ro= 5.7  Ro is the reproduction number, here it means one person with COVID-19 can potentially transmit the coronavirus to 5 to 6 people;


Interesting Insights:

Economy will grow at the beginning few weeks then becoming stagnant for a very long time;

Exposed people are significant, which requires early policies intervention such as social distancing.

Clone of Model of COVID-19 Outbreak in Burnie, Tasmania
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The SEIRS(D) model for the purpose of experimenting with the phenomena of viral spread. I use it for COVID-19 simulation.
Clone of SEIR - COVID-19 (v.1)
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системное моделирование
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COVID-19 in Japan СРС-1
5 months ago
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Here we have a basic SEIR model and we will investigate what changes would be appropriate for modelling the 2019 Coronavirus 

ECM-Training - SEIR Infectious Disease Model for COVID-19
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Өзіндік жұмыс агенттік
5 months ago
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agent base of covid-19 in Republic France 2019-2023
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SIRD COVID-19 Хубэй
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A sample model for class discussion modeling COVID-19 outbreaks and responses from government with the effect on the local economy.  Govt policy is dependent on reported COVID-19 cases, which in turn depend on testing rates less those who recover

Assumptions
The government has reduced both the epidemic and economic development by controlling immigration.




Yuhao c, BMA708_Marketing insights into Big Data.
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A Model for COVID-19 outbreak
AT3
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Recent COVID-19 Outbreak in Burnie Tasmania
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Das SEIRS(D)-Modell zum Simulieren der COVID-19 - Epidemie.
SEIR - COVID-19 (v.1) von Remigiusz Kinas
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Covid-19 Modell