Systems-Biology Models

These models and simulations have been tagged “Systems-Biology”.

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Summary of John Holland's 2012 Book, Signals and Boundaries. Integrator of Classifier, Chemical and Network Adaptive Control and Dynamic Boundaries
Signals and Boundaries
Profile photo Geoff McDonnell
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Simulation model of dynamics published in:  

Kholodenko, B. N. (2000). Negative feedback and ultrasensitivity can bring about oscillations in the mitogen‐activated protein kinase cascades. European Journal of Biochemistry, 267(6), 1583-1588.
MAPK cascade after Kholodenko 2000
Profile photo Jeff Klemens
Insight diagram
Simulation model of dynamics published in:  

Kholodenko, B. N. (2000). Negative feedback and ultrasensitivity can bring about oscillations in the mitogen‐activated protein kinase cascades. European Journal of Biochemistry, 267(6), 1583-1588.
Adjustable MAPK cascade after Kholodenko 2000
Profile photo Jeff Klemens
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Nested multiscale structures, functions and interactions based on Christian Moore Anderson biogogy blog entries
Biology Concept Maps
Profile photo Geoff McDonnell
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WIP based on Uri Alon's 2024-5 course on Systems Aging repeated in 2025-6 System biology of aging and longevity comprising 12 chapters
Systems Aging
Profile photo Geoff McDonnell
6 2 weeks ago
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WIP based on Chapter 1 Universal patterns of ageing and Chapter 2 town garbage analogy of Uri Alon's 2024-5 course on Systems Aging repeated in 2025-6 System biology of aging and longevity 
Systems Aging Ch1 Patterns and Ch2 Metaphor
Profile photo Geoff McDonnell
5 5 days ago
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WIP based on Lecture 4 and 11 of Uri Alon's 2024-5 course on Systems Aging repeated in 2025-6 System biology of aging and longevity 
Systems Aging Longevity genes and evolution
Profile photo Geoff McDonnell
2 weeks ago
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WIP based on Lecture 10 and 11 of Uri Alon's 2024-5 course on Systems Aging repeated in 2025-6 System biology of aging and longevity 
Systems Aging Senolytic Pills and the Saturable removal model
Profile photo Geoff McDonnell
2 weeks ago
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WIP based on Chapters of Uri Alon's 2024-5 course on Systems Aging repeated in 2025-6 System biology of aging and longevity 
Systems Aging Detail 2
Profile photo Geoff McDonnell
2 weeks ago
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WIP based on Lecture 4 of Uri Alon's 2024-5 course on Systems Aging repeated in 2025-6 System biology of aging and longevity 
Systems Aging Menopause
Profile photo Geoff McDonnell
2 weeks ago
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WIP based on Chapter 3 Age Related Diseases of Uri Alon's 2024-5 course on Systems Aging repeated in 2025-6 System biology of aging and longevity 
Systems Aging Detail of Age related Diseases
Profile photo Geoff McDonnell
2 weeks ago