This model works in units of genes per year. It is assumed that Transcription, Repair and the Food Queue are all in Gene units in spite of their having different functions. The Repair process repairs Genes per year. The Transcription process transcribes Genes per year and the Exogenous Food source adds Food in Genes needed to process it per year. Transcription proportion is in Genes (10 of them split between transcription and repair). Other variables like Damage and CpG are dimensionless.
newstrategyclean
Level of biological organization linking cell level division and population level evolution
Biology levels and genetics
Modeling 5: Gene Regulation
A basic production model showing negative and positive loops, often called a balancing model.
Thanks
Gene.
Balancing loop model
System Modeling 5: Gene Regulation
WIP Summary of Cell Systems 2024 article Versatile system cores as a conceptual basis
for generality in cell and developmental biology
Core and periphery hypothesis for cells and developmental systems
System Modeling 5: Gene Regulation Instructions
WIP for planning some relevant online M&S Learning Communities for Health
Online Health Modelling and Simulation Communities
SM5: Gene Regulation Instructions
Small Intestine example from Progress in Biophysics & Molecular Biology Special Issue 2016 From the century of the genome to the century of the organism: New theoretical approaches paper on organization. Compare with Bogdanov (click tag)
Biology Principles of Organization and Variation 1
William T. Powers insight that animate behavior is the purposeful control of perception. Behavior exists to control perceptual signals; internal reference signals are purposes. Continual reorganization of ends and means in the face of obstacles is Learning.
The Control of Perception
Genética, GSD - Liliana, André, Leonor
From Fig 12.2 p317 Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis
Development dynamic interactions
Causal loop diagram illustrating how evolution, in the form of small incremental change (realized through random genetic mutation) paired with natural selection, serves to evolve species.
Additionally, the diagram illustrates the countering effects of genetic drift, which serves to reduce genetic variation by eliminating beneficial genes.
Evolutionary Change (2-Loop)
WIP based mostly on Jan
Toporowski
2013 vol 1 and
2018 vol 2 books on Michal Kalecki: An Intellectual Biography
Layout Consistent with David Wheat MacroEconomic model CLD Insight by Gene Bellinger
Kalecki economic thought
An example of why it's so critical to understand where the boundaries are when considering a system. (developed from Eric Wolstenholme's Archetype examples by Gene Bellinger)
YouTube Video
Hospital Early Discharge Boundaries
This is the Project Challenge in the Insight Maker Essentials lesson on Kumu. This lesson was developed by Gene Bellinger. I developed this relationship diagram as I was following along watching Gene introduce Insight Maker.
20150711a_Project
Modified from Sterman (2006) article and Gene Bellinger's Assumptions IM-351 by Dr Rosemarie Sadsad UNSW See also Complex Decision Technologies IM and IM-63975
Virtual Experiments
