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Model 5: Gene Regulation
2 months ago
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Simple regulated gene
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copied from: Gene Bellinger (Shifting the Burden Archetype | Insight Maker)

A shifting the burden structure occurs when there are different ways to address a situation. With one approach being easier, faster, and requiring fewer resources, which do you think gets pursued? The problem is that taking the easier path ensures one will have to take the easier path repeatedly, and makes it harder to pursue the long-term better solution. See also Archetypes.
Shifting the Burden Archetype
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Causal loop diagram illustrating how evolution, in the form of small incremental change (realized through random genetic mutation) paired with natural selection, serves to evolve species.

Additionally, the diagram illustrates the countering effects of genetic drift, which serves to reduce genetic variation by eliminating beneficial genes.
Evolutionary Change (2-Loop)
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Level of biological organization linking cell level division and population level evolution
Biology levels and genetics
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Modeling 5: Gene Regulation
2 months ago
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Small Intestine example from Progress in Biophysics & Molecular Biology Special Issue 2016 From the century of the genome to the century of the organism: New theoretical approaches paper on organization. Compare with Bogdanov (click tag)
Biology Principles of Organization and Variation 1
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System Modeling 5: Gene Regulation
2 months ago
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System Modeling 5: Gene Regulation Instructions
2 months ago
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As part of becoming familiar with InsightMaker, the purpose of this model is to merely replicate Gene Bellinger's completed "Moose_Wolves" model.  

All credit needs to be given to Gene.   Thank you InsightMaker.com for making it so easy to rebuilt and model and provide details on equations, algorithms.  
Moose Wolves v01
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GSD simulation
Genética, GSD - Liliana, André, Leonor
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Causal loop diagram provided by Gene Bellinger in Projects folder using his AI prompts for Gemini. See also World 2 simulation insight
Limits to Growth (simplified World 3) Causal loop diagram
2 months ago
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SM5: Gene Regulation Instructions
2 months ago
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Adapted from Fig.1. and 2, from Ana V Diez Roux (2011) Complex Systems Thinking May Help Us Transcend Current Impasses in Health Disparities Research Am J Public Health 2011;101 1627-1634  http://ajph.aphapublications.org/cgi/content/abstract/101/9/1627?etoc

Genes environment and health disparities interplay
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Gene infusion
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Gene Regulation
2 months ago
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From Fig 12.2 p317 Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis
Development dynamic interactions
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WIP based mostly on Jan Toporowski 2013 vol 1 and 2018 vol 2 books on Michal Kalecki: An Intellectual Biography  
Layout Consistent with David Wheat MacroEconomic model CLD Insight by Gene Bellinger  
Kalecki economic thought
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Assignment 1 (Final)
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Flow example for Gene
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copied from: Gene Bellinger (Success to the Successful Archetype | Insight Maker)

Success to the successful archetype represents two reinforcing structures which may be in a delicate balance though as soon as one gains a small advantage the resource allocation favors the more successful and the result is then rapidly skewed in the direction of the more successful. See also Archetypes.
Success to the Successful Archetype
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Fixes that Fail Archetype (Cite: Gene Bellinger)
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WIP for planning  some relevant online M&S Learning Communities for Health
Online Health Modelling and Simulation Communities