Gene Regulation Instructions - System Modeling 5
Adapted from Fig.1. and 2, from Ana V Diez Roux (2011) Complex Systems Thinking May Help Us Transcend Current Impasses in Health Disparities Research Am J Public Health 2011;101 1627-1634 http://ajph.aphapublications.org/cgi/content/abstract/101/9/1627?etoc
Genes environment and health disparities interplay
Level of biological organization linking cell level division and population level evolution
Biology levels and genetics
System Modeling 5: Gene Regulation
Modeling 5: Gene Regulation
Go to Gene Bellinger's insight version with video link This common archetype of systems that include relapse or recidivism allows exploration of the unintended effects of increasing upstream capacity and swamping downstream capacity. The increase in the relapse rate eventually returns to swamp upstream capacity as well. A social welfare example, based on a TANF case study, from How Small System Dynamics Models Can Help the Policy Process. N. Ghaffarzadegan, J. Lyneis, GP Richardson. System Dynamics Review 27,1 (2011) 22-44 abstract Conference version here
Swamping Insight
System Modeling 5: Gene Regulation Instructions
From Fig 1.1 p11 Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis. This is a shift in emphasis from statistical correlation to mechanistic causation (p12), including the conditions for the origin and innovation of traits (p13). It overcomes the gradualism, externalism and gene centrism of the Modern Synthesis. Non-gradual change is a property of complex dynamical systems. EvoDevo processes generate particular forms of change rather than others.Genes are followers in the evolutionary process that capture the emergent interactions among environment, development and inheritance into genetic-epigenetic circuits, which are passed to and elaborated on in subsequent generations (p14).
Evolution extended synthesis
Small Intestine example from Progress in Biophysics & Molecular Biology Special Issue 2016 From the century of the genome to the century of the organism: New theoretical approaches paper on organization. Compare with Bogdanov (click tag)
Biology Principles of Organization and Variation 1
SM5: Gene Regulation Instructions
This is a stock-flow consistent model, namely a modified version of the simplest (PC) model with money and boonds.
Godley/Lavoie (2006), chapter 4
(I had to change the equation for consumption demand. The disposable income now enters with a time lag of one period. Otherwise the model would be recursive and would not work in Insight Maker. Thanks to Gene for support.)designed by Dirk Ehnts (blog)
PC model
Clone of Assignment 1 Final
Conceptual Model of Yeast Sugar Uptake
Summary of evolution and the modern synthesis with genetics. See also the more recent extended synthesis IM-2099
Evolution
WIP based mostly on Jan
Toporowski
2013 vol 1 and
2018 vol 2 books on Michal Kalecki: An Intellectual Biography
Layout Consistent with David Wheat MacroEconomic model CLD Insight by Gene Bellinger
Kalecki economic thought
copied from: Gene Bellinger (Shifting the Burden Archetype | Insight Maker)
A shifting the burden structure occurs when there are different ways to address a situation. With one approach being easier, faster, and requiring fewer resources, which do you think gets pursued? The problem is that taking the easier path ensures one will have to take the easier path repeatedly, and makes it harder to pursue the long-term better solution. See also
Archetypes.
Shifting the Burden Archetype
Radioaktiver Zerfall nach Beispiel des exponentiellen Zerfall-Modells von Gene Bellinger
Radioaktiver Zerfall