Level of biological organization linking cell level division and population level evolution
Biology levels and genetics
WIP Summary of Cell Systems 2024 article Versatile system cores as a conceptual basis
for generality in cell and developmental biology
Core and periphery hypothesis for cells and developmental systems
Modeling 5: Gene Regulation
System Modeling 5: Gene Regulation
Adapted from Fig.1. and 2, from Ana V Diez Roux (2011) Complex Systems Thinking May Help Us Transcend Current Impasses in Health Disparities Research Am J Public Health 2011;101 1627-1634 http://ajph.aphapublications.org/cgi/content/abstract/101/9/1627?etoc
Genes environment and health disparities interplay
As part of becoming familiar with InsightMaker, the purpose of this model is to merely replicate Gene Bellinger's completed "Moose_Wolves" model.
All credit needs to be given to Gene. Thank you InsightMaker.com for making it so easy to rebuilt and model and provide details on equations, algorithms.
Moose Wolves v01
copied from: Gene Bellinger (Shifting the Burden Archetype | Insight Maker)
A shifting the burden structure occurs when there are different ways to address a situation. With one approach being easier, faster, and requiring fewer resources, which do you think gets pursued? The problem is that taking the easier path ensures one will have to take the easier path repeatedly, and makes it harder to pursue the long-term better solution. See also
Archetypes.
Shifting the Burden Archetype
Small Intestine example from Progress in Biophysics & Molecular Biology Special Issue 2016 From the century of the genome to the century of the organism: New theoretical approaches paper on organization. Compare with Bogdanov (click tag)
Biology Principles of Organization and Variation 1
System Modeling 5: Gene Regulation Instructions
SM5: Gene Regulation Instructions
Genética, GSD - Liliana, André, Leonor
Causal loop diagram illustrating how evolution, in the form of small incremental change (realized through random genetic mutation) paired with natural selection, serves to evolve species.
Additionally, the diagram illustrates the countering effects of genetic drift, which serves to reduce genetic variation by eliminating beneficial genes.
Evolutionary Change (2-Loop)
From Fig 12.2 p317 Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis
Development dynamic interactions
Causal loop extension of Gene Bellinger's Busy being stuck post, from my gemini interaction after uploading his json file Resistance to betterment (from folder) See also insight Organizational-Traps-Argyris and insight Managing mess
Stuck in the mess
copied from: Gene Bellinger (Success to the Successful Archetype | Insight Maker)
Success to the successful archetype represents two reinforcing structures which may be in a delicate balance though as soon as one gains a small advantage the resource allocation favors the more successful and the result is then rapidly skewed in the direction of the more successful. See also
Archetypes.
Success to the Successful Archetype
The limits to growth structure is based on the basic growth structure. And, as should be obvious, nothing grows forever as growth requires resources. Those required resources become a limits to growth.
Clone of Limits to Growth Archetype (Cite: Gene Bellinger)
WIP based mostly on Jan
Toporowski
2013 vol 1 and
2018 vol 2 books on Michal Kalecki: An Intellectual Biography
Layout Consistent with David Wheat MacroEconomic model CLD Insight by Gene Bellinger
Kalecki economic thought