This model works in units of genes per year. It is assumed that Transcription, Repair and the Food Queue are all in Gene units in spite of their having different functions. The Repair process repairs Genes per year. The Transcription process transcribes Genes per year and the Exogenous Food source adds Food in Genes needed to process it per year. Transcription proportion is in Genes (10 of them split between transcription and repair). Other variables like Damage and CpG are dimensionless.
newstrategyclean
A basic production model showing negative and positive loops, often called a balancing model.
Thanks
Gene.
Balancing loop model
copied from: Gene Bellinger (Shifting the Burden Archetype | Insight Maker)
A shifting the burden structure occurs when there are different ways to address a situation. With one approach being easier, faster, and requiring fewer resources, which do you think gets pursued? The problem is that taking the easier path ensures one will have to take the easier path repeatedly, and makes it harder to pursue the long-term better solution. See also
Archetypes.
Shifting the Burden Archetype
WIP Summary of Cell Systems 2024 article Versatile system cores as a conceptual basis
for generality in cell and developmental biology
Core and periphery hypothesis for cells and developmental systems
Small Intestine example from Progress in Biophysics & Molecular Biology Special Issue 2016 From the century of the genome to the century of the organism: New theoretical approaches paper on organization. Compare with Bogdanov (click tag)
Biology Principles of Organization and Variation 1
Level of biological organization linking cell level division and population level evolution
Biology levels and genetics
Genética, GSD - Liliana, André, Leonor
Concept maps help us to organize and integrate concepts from one or several sources or fields.
orange = Ochman et al. 2000
green = Fierer et al. 2010
purple = Barbaren et al. 2014
1/20
WIP for planning some relevant online M&S Learning Communities for Health
Online Health Modelling and Simulation Communities
Causal loop diagram illustrating how evolution, in the form of small incremental change (realized through random genetic mutation) paired with natural selection, serves to evolve species.
Additionally, the diagram illustrates the countering effects of genetic drift, which serves to reduce genetic variation by eliminating beneficial genes.
Evolutionary Change (2-Loop)
Gene Bellinger's CST course requires several causation models to be developed. This is my first sheet of such models.
Certified Systems Thinker #1
From the Plausibility of life book esp p 220-227 Constraints that deconstrain
Facilitated Variation and Evolvability
Janeways Immunobiology 9th Edition
WIP based mostly on Jan
Toporowski
2013 vol 1 and
2018 vol 2 books on Michal Kalecki: An Intellectual Biography
Layout Consistent with David Wheat MacroEconomic model CLD Insight by Gene Bellinger
Kalecki economic thought
Gene Bellinger's version (AI assisted) of how to overcome short term reductionist problem solving and defensive behaviors common in human organizations See his AMA project
folder1 and
folder2 for more details
Compare with Chris Argyris IM
Overcoming organization defences
From Fig 12.2 p317 Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis
Development dynamic interactions
This is the Project Challenge in the Insight Maker Essentials lesson on Kumu. This lesson was developed by Gene Bellinger. I developed this relationship diagram as I was following along watching Gene introduce Insight Maker.
20150711a_Project
What influences sleep quality?
Homework for systems thinking course by Gene Bellinger
SLEEP