High altitude environments challenge the physiology of mammals mainly due to hypoxic conditions. As a response to this, many mammals show molecular adaptations e.g. by mutations in the genes encoding the hemoglobins. This can result in an increase O2 affinity (and thereby a leftshifted O2 dissociation curve) which will enhance the pulmonary loading of O2. However, the shift can also hamper the O2 unloading process to the metabolic tissue. To elucidate this trade-off between loading and unloading a numerical computer model was made in the program Insigt maker based on the organism, deer mouse (Peromyscus maniculatus). The numerical solution was calculated by the Runge-Kutta method. A time step (dt) of 0.00001 was chosen, as the results were independent of dt at this value. This was tested by investigating the residual values of an interval of dt around 0.00001. The model showed how the trade-off is expressed at different altitudes and how the degree of advantages/disadvantages varies. Based on the model it can be suggested that the trade-off is beneficial, when the hypoxia is severe at high altitude. This is consistent with previously findings. 

 

 Learning THread for hybrid models including Grimm's ODD and Nate Osgood's ABM Modeling Process and Courses

This model contains components supporting the Fire the Bunch example for Systemic Perspective Development Guide.

Challenge the assumptions around aging AR symptoms 

1. The named issues are potential problem statements-in my experience these are the least likely cause.  

2. We can conclude the same lower probability and unlikely to be the actual source of the problem.   

In high tech or industries with products and services we can assume the introduction of stronger controls around software and management of the software when forced into a product model.   The primary threat for most ADVANCED or medium risk.  
While some cases may have the probability to be simply resource performance or lack of.  

The most common problem which has been associated with the complaints or problem targets in this model have more to do with understanding the different revenue triggers in an offer.

Serious again AR reports with specific customers of higher dollar amounts, two distinct patterns identified

1. High Dollar large Enterprise or Global Customer

AND 

2. Aging beyond 90 days

In the situations where both 1 & 2 are true; assume a different problem.  Large customers typically do not buy boxes.  These customers can buy in bulk at discounted rates.  

If a customer purchased from you and you are not a large distribution house or similar sized strategic partner with other large customers.  You are far more likely to be moving from boxes to solutions.   The growing pains tend to be greatest around unpaid invoices in AR.  

Not having a resource or business model to support the solution concept?  Dig deeper-3rd party service providers may be doing the work.  

Custom solutions are always new-as these models are never straightforward and no two solution providers have managed to deliver in the same way.  

Prevent

The highway analogy was designed specifically for this purpose.  

See the "offer type" to aid in the way you might distinguish between the various growing pains.   

See the two sections near the end of the prezi which supply the context for comparing inputs from supplier expenses to inputs from revenue.   
http://prezi.com/zermje-isahd/1-design-strategy-and-value-for-your-new-coaching-business/

Each lane corresponds to the low=Fast lane, medium=middle and high = Slow lane

Solutions
In the North Bound direction, you can assume payment upon reaching the final destination. In some cases we are talking about a year.  

If not a solution - then you are likely dealing with other problems such as...
Do partial shipments prompt an invoice?   

Customers will most often pay when all components are shipped and actually mark your organization lower for making their effort higher to check in each part or the components individually.   

The customers warehouse moves often throughout the day, the chances of losing components are greater and problematic. In the voice of the customer you will find many customers know the problem can be avoided if your process shipped all components upon the full orders readiness.    

Does the invoice issue based on shipment of product or software?  

A server without the license admin - cannot be billed until registration of the software.  

Hardware must be loaded to download or load from CD an admin server seat.  

No clients nor the Server admin can be invoiced until the various hardware components are complete and tested.  

Revenue recognition on the hardware may be the price for a server and all components.  The customer can dispute the invoice until the point of registration of the server admin.  

Drop ship from supplier to customer initiates an invoice?
When drop ship prompts an invoice the process must be redefine to align with the appropriate risk type.   

Auditors will eventually realize your invoice issue and ability to accurately

 Learning THreads IM-2879, integrated with Grimm's ODD and Nate Osgood's ABM Modeling Process and Courses

New Learning tend to reduce Outdated Thinking, Communicating & Learning though our Outdated Thinking, Communicating & Learning inhibits new learning. The question is then how do we break this cycle. Adopted from "An Introduction to Systems Thinking with STELLA" by Barry Richmond.

 Learning THreads IM-2879, integrated with Grimm's ODD and Nate Osgood's ABM Modeling Process and Courses

New Learning tend to reduce Outdated Thinking, Communicating & Learning though our Outdated Thinking, Communicating & Learning inhibits new learning. The question is then how do we break this cycle. Adopted from "An Introduction to Systems Thinking with STELLA" by Barry Richmond.

WIP for planning  some relevant online M&S Learning Communities for Health

 Learning THread for hybrid models including Grimm's ODD and Nate Osgood's ABM Modeling Process and Courses

New Learning tend to reduce Outdated Thinking, Communicating & Learning though our Outdated Thinking, Communicating & Learning inhibits new learning. The question is then how do we break this cycle. Adopted from "An Introduction to Systems Thinking with STELLA" by Barry Richmond.

​From Fig 1.1 p11  Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis

Grimm's ODD and Nate Osgood's ABM Modeling Process and Courses See also Pattern Oriented Modelling IM-3834

From Jennifer Prah Ruger (2010) Health Capability Conceptualization and Operationalization Am J Public Health 100 p41-49 available from SSRN. Extends Insight 779 with Dahlgren and Whitehead's Sunrise Diagram of Social Determinants of Health added. See also wikipedia Capability Approach

Our computer model details the change in allele frequency of resistant mosquitoes in Africa when the government began spraying DDT. The few mosquitoes that naturally survived the chemical sprays reproduced, and created a large population of resistant mosquitoes. When DDT was sprayed later to prevent the spread of malaria, the DDT was not as effective because of the large amount of DDT-resistant phenotypes in the population.

Our computer model details the change in allele frequency of resistant mosquitoes in Africa when the government began spraying DDT. The few mosquitoes that naturally survived the chemical sprays reproduced, and created a large population of resistant mosquitoes. When DDT was sprayed later to prevent the spread of malaria, the DDT was not as effective because of the large amount of DDT-resistant phenotypes in the population.

Our computer model details the change in allele frequency of resistant mosquitoes in Africa when the government began spraying DDT. The few mosquitoes that naturally survived the chemical sprays reproduced, and created a large population of resistant mosquitoes. When DDT was sprayed later to prevent the spread of malaria, the DDT was not as effective because of the large amount of DDT-resistant phenotypes in the population.

Our computer model details the change in allele frequency of resistant mosquitoes in Africa when the government began spraying DDT. The few mosquitoes that naturally survived the chemical sprays reproduced, and created a large population of resistant mosquitoes. When DDT was sprayed later to prevent the spread of malaria, the DDT was not as effective because of the large amount of DDT-resistant phenotypes in the population.