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Examples of macroanalysis relevant to representing causal mechanisms linking genes to diseases from darden2018 MecCog article and 2017 Product to Process article
Mechanistic Reasoning from Genotype to Phenotype
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System Modeling 4
2 weeks ago
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Initial AI plus Nobel Prize Economics 2025 lecture then second session with Gene Bellinger Nov 2025 See also TIE insight and Critique Insight
The Middle Income Trap
3 months ago
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 Learning THread for hybrid models including Grimm's ODD and Nate Osgood's ABM Modeling Process and Courses

Clone of Dynamic Models Learning Content
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Categorical systems theory applied to health services integration and surge response based on my March2026 Gemini interaction using Gene Bellinger's AI prompts. See more complete health service reliability insight based on emery roe's work
Category Theory in Health Services Integration and Surge Response
3 weeks ago
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to draw out structures and dynamics

  • healthcare is a wonderful product; countries are spending increasing amount [of increasing GDP] on healthcare ... 20% by 2050?
  • tend to apply new technologies to too many people...will become more targeted
  • build on what works and fix what doesn't cf with radical model shift
  • last two years of life consume most healthcare
  • 1% accounts for 35% of cost [chronic conditions and how we treat dying people]
  • shift to outcome based vs input [time based] or output based [procedures] ... ok at population level otherwise presumes accurate diagnosis and less co-morbidity?
  • Geisinger salaried medical staff + quality bonus [rather than no. of patients treated]
Health Sector
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The following is a cross between the Lotka-Volterra Predator-Prey model from the Insight Maker manual  (https://insightmaker.com/node/3801) where the Moose represent problem symptoms, the Wolves represent temporary solution, and the addiction loop from Gene Bellinger's Addiction Archetype (https://insightmaker.com/insight/25461/Addiction-Archetype) is added.
Clone of Lotka–Volterra Addiction Model
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Clone of Logística de chontalpa
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This is a copy of Gene Bellinger's "Balancing Loop" Insight. I just did it to see if I could get something running! It works!

Test balancing loop
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System Modeling 5
2 weeks ago
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System Modeling 4: Protein Formation
2 weeks ago
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As part of becoming familiar with InsightMaker, the purpose of this model is to merely replicate Gene Bellinger's completed "Moose_Wolves" model.  

All credit needs to be given to Gene.   Thank you InsightMaker.com for making it so easy to rebuilt and model and provide details on equations, algorithms.  
Clone of Moose Wolves v01
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Ograniczenie wzrostu IT
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Insecticide Resistance In Mosquitoes
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From Fig 12.2 p317 Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis
Clone of Development dynamic interactions
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Protein Production
System Map 4
2 months ago
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CIVE: Progress Report 1
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Unfolding causal loop story of Chris Argyris' famous Harvard Business Review article inspired by Gene Bellinger's AI assisted kumu summary  
Teaching smart people how to learn
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Protein Production
2 months ago
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System model 4
2 months ago
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The Moran process: the simplest possible selection process in a population of two traits A and B. In each generation, a random part of the population is chosen to reproduce at the expense of the opposite trait.

The take-home message is this: random genetic drift always leads to one species supplanting another, but only if the drift is sufficiently particulate. As the drift becomes more and more continuous, so the duration of the fixation process approaches infinity.

To test this, start with mu=1 and notice that the simulation quickly runs to fixation (either A or B equal to 10). mu is the quantity of population that mutate between A and B in a single generation. For mu=1, this means all individuals in either the A or B population transfer to the other side in the first generation, so clearly fixation occurs in the first generation.

But now reduce mu to 0.5, and notice that fixation takes a little longer. Then try mu = 0.25, 0.2, 0.1, 0.05 and 0.01 and notice how long fixation takes.

This was Gregor Mendel's great insight: genes are particulate. If they were not, traits would not fixate, but would instead smear over time into averaged trait values.
Moran
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System Modeling 4
2 months ago
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An example of why it's so critical to understand where the boundaries are when considering a system. Go to Gene's version insight
Clone of Hospital Early Discharge Boundaries (Old version)