Gene Regulation Instructions - System Modeling 5
System Modeling 5: Gene Regulation
Level of biological organization linking cell level division and population level evolution
Biology levels and genetics
See Gene's excellent explication at
https://www.youtube.com/watch?v=k22rDovFzUE
Conveyor per Gene
Book Summary based on Terry Sampson's summary of Philip Ball's May 2024 Royal Society presentation. A causal loop scaffolding using Gene Bellinger's mc and mr AI prompts for Gemini added in Jan2026. See also Philip Ball's article summary insight
How Life Works Book Summary
Launchpad for insights related to Systems and Complexity in general and Systems Science for Health in particular. Current key participants are public health researchers, health service managers, clinicians, and mental health policy makers and practitioners
My Systems Science Insights
Gene Expression Model II: regulation
SM5: Gene Regulation Instructions
Simplistic Gene Expression Model I: no regulation
A system diagram for the Mojave Desert for an assignment at OSU- RNG 341.
Mojave Desert System Diagram
When Trp isn't in big quantities in a cell, the Trp Operon will remain on, meaning that more and more Trp will be produced. However, if Trp is existent in large quantities in a cell, it will bond to represser proteins and activate them from their inactive state, which will then bond to the Operon to prevent transcription of the Trp gene.
Trp Operon (Taruna's version)
A basic production model showing negative and positive loops, often called a balancing model.
Thanks
Gene.
Balancing loop model
System Modeling 5: Gene Regulation Instructions
Unfolding WIP of Eric Wolstenholme's explanation of hospital congestion from March 2022 Youtube video and online stella presentation. Use of cascading interlinked archetypes. See Kumu version, early discharge boundaries IM for an earlier version and Generic Archetypes IM from Gene and Simpler Version IM
Hospital congestion cascading archetypes
This model works in units of genes per year. It is assumed that Transcription, Repair and the Food Queue are all in Gene units in spite of their having different functions. The Repair process repairs Genes per year. The Transcription process transcribes Genes per year and the Exogenous Food source adds Food in Genes needed to process it per year. Transcription proportion is in Genes (10 of them split between transcription and repair). Other variables like Damage and CpG are dimensionless.
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