Find Insights | Insight Maker

Tipos de Mutaciones

Joaquin Asad

WIP based mostly on Jan Toporowski 2013 vol 1 and 2018 vol 2 books on Michal Kalecki: An Intellectual Biography

Layout Consistent with David Wheat MacroEconomic model CLD Insight by Gene Bellinger

Kalecki economic thought

Geoff McDonnell

This model works in units of genes per year. It is assumed that Transcription, Repair and the Food Queue are all in Gene units in spite of their having different functions. The Repair process repairs Genes per year. The Transcription process transcribes Genes per year and the Exogenous Food source adds Food in Genes needed to process it per year. Transcription proportion is in Genes (10 of them split between transcription and repair). Other variables like Damage and CpG are dimensionless.

newstrategyclean

james dart

GSD simulation

Genética, GSD - Liliana, André, Leonor

André da Silva

4

WIP Based on Gene's Enabling a Better Tomorrow Map IM-2879 this is a Specific Health Care version based on the archived Systemswiki Health Care material. The focus is on Models and Simulation, with videos and discussion in the fullness of time. I am following Gene's Adventures in Wonderland framework. Revised for More Complex AnyLogic transition at IM-57331

Health Systems and Data Science Course

Geoff McDonnell

3 9 months ago

Gene editing simulation

aayushi

5 months ago

From Fig 1.1 p11 Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis. This is a shift in emphasis from statistical correlation to mechanistic causation (p12), including the conditions for the origin and innovation of traits (p13). It overcomes the gradualism, externalism and gene centrism of the Modern Synthesis. Non-gradual change is a property of complex dynamical systems. EvoDevo processes generate particular forms of change rather than others.Genes are followers in the evolutionary process that capture the emergent interactions among environment, development and inheritance into genetic-epigenetic circuits, which are passed to and elaborated on in subsequent generations (p14).

Evolution extended synthesis

Geoff McDonnell

Gene infusion

Travis Collins

From Fig 12.2 p317 Pigliucci M and Muller GB (2010) Evolution: The Extended Synthesis

Development dynamic interactions

Geoff McDonnell

Causal loop diagram illustrating how evolution, in the form of small incremental change (realized through random genetic mutation) paired with natural selection, serves to evolve species.

Additionally, the diagram illustrates the countering effects of genetic drift, which serves to reduce genetic variation by eliminating beneficial genes.

Evolutionary Change (2-Loop)

Franz Weismann

3

Radioaktiver Zerfall nach Beispiel des exponentiellen Zerfall-Modells von Gene Bellinger

Radioaktiver Zerfall

Cornelius Frank

Adapted from Fig 2, from Ana V Diez Roux (2011) Complex Systems Thinking May Help Us Transcend Current Impasses in Health Disparities Research Am J Public Health 2011;101 1627-1634 http://ajph.aphapublications.org/cgi/content/abstract/101/9/1627?etoc

Genes environment and physical activity interplay

Geoff McDonnell

New Learning tend to reduce Outdated Thinking, Communicating & Learning though our Outdated Thinking, Communicating & Learning inhibits new learning. The question is then how do we break this cycle. Adopted from "An Introduction to Systems Thinking with STELLA" by Barry Richmond.

@LinkedIn, Twitter, YouTube

New Learning Inhibited/Breaking the Cycle

Gene Bellinger

3

Adapted from Fig.1.from Ana V Diez Roux (2011) Complex Systems Thinking May Help Us Transcend Current Impasses in Health Disparities Research Am J Public Health 2011;101 1627-1634 http://ajph.aphapublications.org/cgi/content/abstract/101/9/1627?etoc

Genes environment and health disparities

Geoff McDonnell

Unfolding WIP of Eric Wolstenholme's explanation of hospital congestion from March 2022 Youtube video and online stella presentation. Use of cascading interlinked archetypes. See Kumu version, early discharge boundaries IM for an earlier version and Generic Archetypes IM from Gene and Simpler Version IM

Hospital congestion cascading archetypes

Geoff McDonnell

9 months ago

,

Tragedy of the Commons Archetype (Cite: Gene Bellinger)

Jake Jacobson

Coping but not coping in health and social care: masking the reality of running organisations beyond safe design capacity. From Eric Wolstenholme Syst. Dyn. Rev. 23, 371–389, (2007) abstract. See also IM-1010 for unfolding CLD version. This is a cascade of swamping structures see gene's insight with video link

Coping but not coping stock flow 2007

Geoff McDonnell

9 months ago

SMN

burawundi@yahoo.com

Assignment 1 Final

Paras Gupta

3

Small Intestine example from Progress in Biophysics & Molecular Biology Special Issue 2016 From the century of the genome to the century of the organism: New theoretical approaches paper on organization. Compare with Bogdanov (click tag)

Biology Principles of Organization and Variation 1

Geoff McDonnell

5 months ago