WIP From  zenker 2007 article PLoS Computational Biology From Inverse Problems in Mathematical Physiology to Quantitative Differential Diagnoses

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

WIP Book Summary 

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Dosage per day, Doses per day, Every ? hours, Medicine in Intestines, Drug absorption, Plasma level, Blood volume, Plasma concentration, ​Toxic level, Medicinal level, Drug excretion, Excretion rate, Half-Life

Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Alternate Layout of insight IM-857 Here Join and Split Flows are unfolded rather than using folders around the Stocks.

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

Stock flow map of Immune System Cell type proliferation and differentiation, migration and circulation from Figs 1.3, 8.14 and 8.33 from Janeway's Immunobiology see Insight . Does not include cell death, interactions or inhibitory and promoting factors

Dosage per day, Doses per day, Every ? hours, Medicine in Intestines, Drug absorption, Plasma level, Blood volume, Plasma concentration, ​Toxic level, Medicinal level, Drug excretion, Excretion rate, Half-Life

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

Dosage per day, Doses per day, Every ? hours, Medicine in Intestines, Drug absorption, Plasma level, Blood volume, Plasma concentration, ​Toxic level, Medicinal level, Drug excretion, Excretion rate, Half-Life

Modelo Glucosa-Insulina en Diabetes Tipo 1

Part II of Immune System Dynamics showing the Phases of the Immune Response and some details of each phase

REFERENCIAS:

[1] Datos de población total de El Salvador, PIB y su crecimiento (GDP) tomados de:

 The health system of El Salvador

Mónica Acosta, L en CP, María del Rocío Sáenz, MC, Blanca Gutiérrez, M en A, Juan Luis Bermúdez, http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342011000800014

[2] https://www.paho.org/salud-en-las-americas-2017/?post_t_es=el-salvador&lang=es

[3] Base de simulacion tomada de:

Simplified dynamic model, adapted from Engineering perspectives on healthcare delivery: Can we afford technological innovation in healthcare? Rouse, William B Systems Research and Behavioral Science 2009 Vol 26 (5) p573-582 abstract  Developed by Mark Heffernan. Addition of learning curve effects IM-614 to Insight 435

Modelo mínimo de cinética de la glucosa de Bergman, utilizado para calcular la sensibilidad a la insulina a partir de una prueba de tolerancia a la glucosa intravenosa (IVGTT). La insulina plasmática I (t) entra en un compartimento remoto X (t) donde actúa acelerando la desaparición de la glucosa G (t) hacia la periferia y el hígado, e inhibiendo la producción de glucosa hepática

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

Dosage per day, Doses per day, Every ? hours, Medicine in Intestines, Drug absorption, Plasma level, Blood volume, Plasma concentration, ​Toxic level, Medicinal level, Drug excretion, Excretion rate, Half-Life

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.